Work package 3 will be lead by
Organization	Leader		Organization	Leader
	Assoc. Prof. Scheepers	+		Prof. dr. Trevisan

WP3 will deal with the development of exposure estimates for direct and indirect exposures to PPP mixtures relevant to EPAH health by integrating existing data with new data obtained from CSS and come up with innovative exposure assessment models.

The specific objectives for WP3 are:

• To integrate exposure estimates relevant to EPAH health using the Dutch Integrated Exposure Modelling Framework (OBO), which includes IDEFICS, PEARL, BREAM, and OPS-St.
• To calculate exposure of non-target species in ecosystems and uptake in crops with FOCUS fate models using existing datasets and new data from CSS (in connection with WP2), and improve FOCUS fate models including missing modules such as wind erosion.
• To derive direct exposure from existing data on dietary intake and PPPs’ residues in food for humans and feed for animals.
• To estimate non-dietary indirect exposure for animals and humans (inhalation, skin uptake, unintentional ingestion) with the OBO modelling framework, parameterized with existing and new data from our CSS.
• To integrate existing exposure models and calibrate these models for exposure of farmer’s families, non-farmer rural population and consumers, using urinary excretion of metabolites to estimate internal exposure and uptake of PPPs by reverse dosimetry using experimentally calibrated PBPK models for humans.
• To integrate existing models with OBO and parameterize this model for animal exposure (cow, chicken, goat/sheep) and urinary excretion of metabolites is used to estimate internal exposure and recent uptake of PPPs by reverse dosimetry using existing PBPK models.
• To perform sensitivity analyses and present EPAH exposure estimates with information on variability uncertainty, e.g. the influence of data gaps and assumptions.